Table 3.

Donepezil concentrations in human plasma and cerebrospinal fluid and cerebrospinal concentration (% of plasma)

Time interval	Patient no.	Age	MMSE	Donepezil concentration		CSF concentration (% of plasma)
				Plasma (ng/ml)	CSF (ng/ml)
12 h	1	74	18	47.18	4.20	8.90
	2	84	15	17.29	Under LOD	–
	3	83	23	24.09	2.42	10.04
	4	82	17	69.26	4.29	6.19
	5	80	18	44.71	5.10	11.40
	6	75	11	38.54	5.41	14.03
	7	83	19	13.92	Under LOD	–
	8	62	7	43.10	4.80	11.14
	9	85	22	61.38	10.10	16.45
Mean ± SEM				39.99 ± 5.90	5.19 ± 0.83
24 h	1	79	22	29.47	6.24	21.02
	2	73	18	26.93	6.65	24.91
	3	79	27	27.16	5.41	19.85
	4	88	24	40.30	8.62	21.34
	5	78	15	27.14	7.42	27.31
	6	71	17	27.34	9.85	35.90
	7	72	20	27.33	8.62	31.50
Mean ± SEM				29.38 ± 1.71	7.54 ± 0.55