Table 4.
Direct medical costs (US$) by dose adjustment cohort (including ED and hospital visits)
| Component | No dose adjustment, n = 227 | One dose adjustment, n = 122 | Two dose adjustments, n = 47 | Three or more dose adjustments, n = 58 | |||
|---|---|---|---|---|---|---|---|
| Cost per patient (95% CI) | Cost per patient (95% CI) | Difference vs. no dose adjustment group | Cost per patient (95% CI) | Difference vs. no dose adjustment group | Cost per patient (95% CI) | Difference vs. no dose adjustment group | |
| Laboratory tests | $262 ($220–$303) | $422 ($359–$485)*,**** | +$160 | $462 ($366–$558)* | +$200 | $567 ($473–$661)*,** | +$305 |
| Thyroid medication | $546 ($515–$577)***,**** | $623 ($575–$672)**** | +$77 | $565 ($475–$656)*,**** | +$19 | $827 ($572–$1081)*,**,*** | +$281 |
| Specialist visits | $156 ($123–$188) | $159 ($114–$204) | +$3 | $167 ($94–$239) | +$11 | $190 ($115–$265) | +$34 |
| Office visits | $1218 ($1020–$1415)**,**** | $1748 ($1453–$2043)*,**** | +$530 | $1696 ($1299–$2094) | +$478 | $2190 ($1707–$2672)* | +$972 |
| ED visits | $0**,***,**** | $69 ($6–$132)* | +$69 | $15 ($0–$30) | +$15 | $97 ($2–$191)* | +$97 |
| Hospitalizations | $0**,***,**** | $718 ($0–$1435)**** | +$718 | $621 ($0–$1242)**** | +$621 | $2516 ($343–$4689)*,**,*** | +$2516 |
| Total | $2182 ($1955–$2408)**,**** | $3739 ($2695–$4783)*,**** | +$1557 | $3526 ($2271–$4782)**** | +$1344 | $6387 ($4100–$8673)*,**,*** | +$4205 |
Costs use the higher value of estimated cost ranges for this analysis. One-way ANOVA was used to compare costs between cohorts. A Tukey multiple comparison procedure was used following a significant ANOVA result (p < 0.05) where appropriate
ANOVA analysis of variance, CI confidence interval, ED emergency department
* p < 0.05 vs. no dose adjustment group; ** p < 0.05 vs. one dose adjustment group; *** p < 0.05 vs. two dose adjustments group; **** p < 0.05 vs. three or more dose adjustments group