Table 5.
Summary of productivity loss (US$) by dose adjustment cohort
| Component | No dose adjustment, n = 227 | One dose adjustment, n = 122 | Two dose adjustments, n = 47 | Three or more dose adjustments, n = 58 | |||
|---|---|---|---|---|---|---|---|
| Productivity loss per patient (95% CI) | Productivity loss per patient (95% CI) | Difference vs. no dose adjustment group | Productivity loss per patient (95% CI) | Difference vs. no dose adjustment group | Productivity loss per patient (95% CI) | Difference vs. no dose adjustment group | |
| Laboratory tests | $271**,***,**** ($236–$307) | $405*,**** ($353–$457) | +$134 | $458* ($394–$523) | +$187 | $574*,** ($497–$650) | +$303 |
| Specialist visits | $12 ($9–$14) | $12 ($9–$15) | +$0 | $12 ($9–$15) | +$0 | $14 ($9–$20) | +$2 |
| Office visits | $424**,**** ($355-$493) | $609* ($506-$712) | +$185 | $591 ($506−$712) | +$167 | $763* ($595−$931) | +$339 |
| ED visits | $55**** ($37–$73) | $87 ($53–$121) | +$32 | $30**** ($7–$53) | −$25 | $139*,*** ($56–$223) | +$84 |
| Hospitalizations | $222 ($152–$291) | $268 ($162–$375) | +$46 | $71* ($16–$126) | −$151 | $343*** ($152–$535) | +$121 |
| Total | $984**** ($832–$1135) | $1381*,**** ($1157–$1607) | +$397 | $1162**** ($965–$1361) | +$178 | $1833*,**,*** ($1485–$2182) | +$849 |
One-way ANOVA was used to compare costs between cohorts. A Tukey multiple comparison procedure was used following a significant ANOVA result (p < 0.05) where appropriate
ANOVA analysis of variance, CI confidence interval, ED emergency department
* p < 0.05 vs. no dose adjustment group; ** p < 0.05 vs. one dose adjustment group; *** p < 0.05 vs. two dose adjustments group; **** p < 0.05 vs. three or more dose adjustments group