Table 8.
Estimated direct medical costs (US$) among patients with GI conditions
| Component | GI conditions with no dose adjustment, n = 83 | GI conditions with one dose adjustment, n = 53 | GI conditions with two dose adjustments, n = 25 | GI conditions with three or more dose adjustments, n = 25 | |||
|---|---|---|---|---|---|---|---|
| Cost per patient (95% CI) | Cost per patient (95% CI) | Difference vs. no dose adjustment group | Cost per patient (95% CI) | Difference vs. no dose adjustment group | Cost per patient (95% CI) | Difference vs. no dose adjustment group | |
| Laboratory tests | $349 ($266–$432) | $422 ($330–$514) | +$73 | $447 ($311–$583) | +$114 | $524 ($398–$650) | +$175 |
| Thyroid medication | $503**** ($460–$546) | $592 ($523–$661) | +$89 | $484 ($380–$588) | −$19 | $828* ($343–$1300) | +$325 |
| Specialist visits | $224 ($164–$283) | $219 ($141–$297) | −$5 | $174 ($76–$272) | −$50 | $163 ($47–$278) | −$61 |
| Office visits | $1548 ($1142–$1954) | $2364 ($1802–$2926) | +$816 | $1999 ($1341–$2657) | +$451 | $2513 ($1628–$3398) | +$965 |
| ED visits | $0**** | $10 ($0–$211) | +$106 | $28 ($0–$55) | +$28 | $140 ($0–$280) | +$140 |
| Hospitalizations | $0**** | $1101 ($0–$2203) | +$1101 | $0 | +$0 | $3502 ($0–$6998) | +$3502 |
| Total | $2624**** ($2164–$3083) | $4804 ($2778–$6829) | +$2180 | $3148 ($2399–$3866) | +$524 | $7670* ($3518–$11,809) | +$5046 |
Costs use the higher value of estimated cost ranges for this analysis. Column total values are a per-patient average, and are not necessarily equal to the sum of component/row averages. One-way ANOVA was used to compare costs between cohorts. A Tukey multiple comparison procedure was used following a significant ANOVA result (p < 0.05) where appropriate
ANOVA analysis of variance, CI confidence interval, ED emergency department, GI gastrointestinal
* p < 0.05 vs. no dose adjustment group; ** p < 0.05 vs. one dose adjustment group; *** p < 0.05 vs. two dose adjustments group; **** p < 0.05 vs. three or more dose adjustments group