Fig. 3.

Effects of tested aryl-1,3,5-triazine derivatives, JNJ7777120 and Indomethacin on mechanical hyperalgesia developed 3 h after subplantar injection of 1 % carrageenan in rats (Randall–Selitto model). Data are expressed as mean ± S.E.M. n = 6–8 rats per group. The initial reaction considered as the nociceptive reaction before carrageenan administration. V vehicle; I indomethacin; Statistical significance compared to vehicle-treated animals: *p <  0.05, **p <  0.01, ***p <  0.001. Statistical analysis: one-way ANOVA followed by Dunnett’s multiple comparison test