Table 2.
Compound | Concentration (μM) | PDE 4B1 inhibition (%) ± SEM |
---|---|---|
Cmpd 1 | 50 | 7 ± 1.0 |
100 | 9 ± 1.0 | |
Cmpd 2 | 50 | 2 ± 0.0 |
100 | 6 ± 1.0 | |
JNJ7777120 | 50 | 0 ± 0.0 |
100 | 1 ± 0.5 | |
Irsogladine | 50 | 20 ± 2.5 |
100 | 31 ± 0.5 | |
Rolipram | 50 | 95 ± 0.0 |
100 | 98 ± 0.0 |
Percentage of PDE inhibition was calculated in relation to the vehicle control (DMSO)