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. 2016 Oct 20;66(1):79–95. doi: 10.1007/s00011-016-0997-z

Table 2.

Inhibitory effect of investigated and reference compounds for PDE 4B1 (%)

Compound Concentration (μM) PDE 4B1 inhibition (%) ± SEM
Cmpd 1 50 7 ± 1.0
100 9 ± 1.0
Cmpd 2 50 2 ± 0.0
100 6 ± 1.0
JNJ7777120 50 0 ± 0.0
100 1 ± 0.5
Irsogladine 50 20 ± 2.5
100 31 ± 0.5
Rolipram 50 95 ± 0.0
100 98 ± 0.0

Percentage of PDE inhibition was calculated in relation to the vehicle control (DMSO)