Fig. 1. Changes in clinical parameters at 8 months after intervention with either testosterone replacement therapy (TRT group, n=54) or placebo (control group, n=52) in patients with testosterone deficiency syndrome. At 8 months after intervention, the improvement in total testosterone levels, IIEF-5 score, AMS score, and BDI score was significantly higher (^*) in the TRT group than in the control group. ^*p<0.05 compared with control group. Qmax: maximal urinary flow rate, PVR: postvoid residual volume, IIEF-5: 5-item version of the International Index of Erectile Function questionnaire, AMS: Aging Males' Symptoms, BDI: Beck Depression Inventory, K-MMSE: Korean Mini-Mental State Examination.