Table 3.
Sensitivity analyses: coefficients for depressive symptoms at age 14 years (SMFQ⩾11) by unweighted, weighted (including ALSPAC) and weighted (excluding ALSPAC) genetic risk scores
| Coefficient (95% CI) | OR (95% CI)a | P | |
|---|---|---|---|
| Unweighted score | |||
| Association of score with depressive symptoms at 14 | 1.02 (1.005 to 1.04) | 0.01 | |
| Association of score with age at menarche | −0.42 (−0.49 to −0.35)b | <0.001 | |
| Instrumental variable analysis | 0.006 (0.001 to 0.01)c | 0.02 | |
| Weighted score (including ALSPAC) | |||
| Association of score with depressive symptoms at 14 | 1.04 (1.01 to 1.07) | 0.02 | |
| Association of score with age at menarche | −0.86 (−1.00 to −0.72)b | <0.001 | |
| Instrumental variable analysis | 0.006 (0.001 to 0.01)c | 0.03 | |
| Weighted score (excluding ALSPAC) | |||
| Association of score with depressive symptoms at 14 | 1.03 (0.998 to 1.07) | 0.06 | |
| Association of score with age at menarche | −0.74 (−0.89 to −0.59)b | <0.001 | |
| Instrumental variable analysis | 0.006 (−0.001 to 0.01)c | 0.07 | |
SMFQ, Short Moods and Feelings Questionnaire; ALSPAC, Avon Longitudinal Study of Parents and Children.
a.
OR per unit increase in score.
b.
Change in age at menarche in months per unit increase in score.
c.
Risk difference per month decrease in age at menarche.