TABLE 1.

In Vitro Uptake of Promising Compounds in Model Bacteria Representing Major Classes of Pathogens

Name	S. aureus (gram-positive)	E. coli (gram-negative)	P. aeruginosa	Mycobacteria	Macrophages (J774)
l-Arabinose [1-14C]	0.41 ± 0.03	41.61 ± 9.91	0.21 ± 0.02	0.28 ± 0.01 (Mtb)	0.18 ± 0.01
Cellobiose [3H]	1.81 ± 0.10	0.80 ± 0.05	–	0.13 ± 0.02 (Ms)	–
d-Lyxose [1-14C]	0.03 ± 0.01	1.86 ± 0.14	0.12 ± 0.04	0.35 ± 0.08 (Mtb)	0.04 ± 0.01
d-mannitol [1-14C]	68.40 ± 7.39	81.80 ± 1.96	0.69 ± 0.05	0.29 ± 0.13 (Mtb)	0.12 ± 0.01
Methyl-α-d-glucopyranoside [methyl-14C]	11.01 ± 0.71	26.78 ± 0.59	–	0.11 ± 0.01 (Ms)	–
PABA [3,5-3H]	16.82 ± 1.03	18.99 ± 5.80	4.02 ± 1.11	32.93 ± 4.73 (Mtb)	0.11 ± 0.01
l-Rhamnose [3H]	4.96 ± 0.13	4.73 ± 0.07	0.24 ± 0.04	3.82 ± 0.84 (Mtb)	0.60 ± 0.02
Shikimic acid [3-3H]	7.54 ± 0.01	1.52 ± 0.02	1.31 ± 0.02	0.17 ± 0.01 (Ms)	–
d-Sorbitol [14C] (18F-FDS)*	0.47 ± 0.09	72.20 ± 9.09	0.52 ± 0.46	–	0.21 ± 0.01
d-Xylose [1-14C]	0.31 ± 0.01	73.94 ± 2.06	0.53 ± 0.08	0.18 ± 0.02 (Mtb)	0.19 ± 0.01

^*18F-FDS used for uptake assays.

Mtb = Mycobacterium tuberculosis; Ms = Mycobacterium smegmatis.

Data are mean ± SD.