TABLE 1.
PBL model (NSG mice with human PBMCs) |
NSG mice |
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Organ | mGy/MBq | SD | rad/mCi | SD | mGy/MBq | SD | rad/mCi | SD |
Adrenals | 0.028 | 0.001 | 0.104 | 0.001 | 0.028 | 0.001 | 0.105 | 0.001 |
Brain | 0.249 | 0.005 | 0.919 | 0.019 | 0.245 | 0.006 | 0.905 | 0.022 |
Breasts | 0.185 | 0.001 | 0.683 | 0.005 | 0.185 | 0.002 | 0.684 | 0.008 |
Small intestine | 0.025 | 0.001 | 0.091 | 0.001 | 0.025 | 0.001 | 0.091 | 0.001 |
Stomach wall | 0.630 | 0.004 | 2.329 | 0.014 | 0.630 | 0.005 | 2.332 | 0.019 |
Kidneys | 0.030 | 0.001 | 0.113 | 0.005 | 0.035 | 0.001 | 0.128 | 0.005 |
Liver | 1.207 | 0.022 | 4.465 | 0.083 | 1.196 | 0.061 | 4.426 | 0.225 |
Lungs | 0.556 | 0.004 | 2.059 | 0.016 | 0.562 | 0.003 | 2.078 | 0.010 |
Muscle | 0.019 | 0.001 | 0.070 | 0.002 | 0.019 | 0.001 | 0.072 | 0.001 |
Ovaries | 1.591 | 0.006 | 5.885 | 0.023 | 1.594 | 0.013 | 5.897 | 0.046 |
Pancreas | 0.029 | 0.001 | 0.108 | 0.001 | 0.029 | 0.001 | 0.108 | 0.002 |
Red marrow | 0.533 | 0.003 | 1.970 | 0.010 | 0.533 | 0.004 | 1.972 | 0.014 |
Skin | 0.373 | 0.002 | 1.380 | 0.008 | 0.373 | 0.003 | 1.378 | 0.012 |
Spleen | 0.030 | 0.001 | 0.112 | 0.002 | 0.028 | 0.007 | 0.104 | 0.027 |
Thymus | 0.024 | 0.001 | 0.087 | 0.101 | 0.024 | 0.013 | 0.089 | 0.048 |
Salivary glands | 1.246 | 0.082 | 4.609 | 0.013 | 0.838 | 0.004 | 3.099 | 0.014 |
Urinary bladder wall | 0.573 | 0.004 | 2.118 | 0.001 | 0.574 | 0.001 | 2.125 | 0.002 |
Uterus | 0.026 | 0.001 | 0.097 | 0.001 | 0.026 | 0.001 | 0.097 | 0.001 |
Total-body effective dose (mSv/MBq) | 0.597 | 0.005 | 0.581 | 0.003 |