Figure 2. Coordination of ADP by the non-consensus YopO P-loop.

(a) Sequence alignment of P-loop sequences across kinases from different families. Full alignments can be found in Supplementary Fig. 2. (b) Hydrogen-bonding interactions that coordinate the kinase-bound ADP. Magenta spheres represent Mg²⁺ ion in YopO and Mn²⁺ ions in MST3 (PDB: 3A7J) while blue spheres represent water. For clarity, only the side chain is shown for some residues while their attachment to the main chain is represented as a sphere, and the side-chain atoms of residue 143 are not shown.