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. 2017 Jan 4;7:39721. doi: 10.1038/srep39721

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Copyright © 2017, The Author(s)

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(A) Patients with multiple-organ metastases showed a non-significant increase in the percentage of KRAS mutant cases (vs single-organ spread, 32% v 27%). (B) In the organ-specific analysis, patients with brain, bone or adrenal gland metastases demonstrated similar KRAS mutation frequencies (29%, 28% and 33%, respectively). However, pulmonary metastatic cases demonstrated increased KRAS mutation frequency when compared to those with extrapulmonary metastases (35% and 26.5%; p = 0.0125). In contrast, pleural dissemination and liver metastasis associated with decreased KRAS mutation incidence (17% (p < 0.001) and 16% (p = 0.0023), respectively).