Figure 1. Pedigrees of the families in which a putative pathogenic mutation was identified in the panel genes.

Filled quarters of symbols indicate patients affected by cancer (each color refers to a specific type). Current age, age at death and age at diagnosis (in brackets), when available, are also detailed. Putative pathogenic mutations are shown at the top of each pedigree; proband is marked by an arrow, carrier status was studied in available relatives, and those carrying/not carrying the variant are marked with +/− respectively. CRC, colorectal cancer; GBM; glioblastoma; Liposarc., Liposarcoma; LOH, loss of heterozygosity; MDB; medulloblastoma; NOS, not otherwise specified cancer; STS, soft tissue sarcoma.