Table 1.

Patient demographics

	Safety N = 8	Pharmacodynamic N = 16	Overall N = 24
Age (years)
Median (range)	57 (28–72)	70 (38–82)	65 (28–82)
Number of patients
Male	5 (62.5%)	11 (69%)	16 (67%)
Female	3 (37.5%)	5 (31%)	8 (33%)
Primary disease site
Prostate	1 (12.5%)	5 (31%)	6 (25%)
Colorectal	1 (12.5%)	3 (19%)	4 (17%)
Urothelial	0 (0%)	2 (13%)	2 (8%)
Ovarian	1 (12.5%)	1 (6%)	2 (8%)
Lung	1 (12.5%)	1 (6%)	2 (8%)
Other	4 (50%)	4 (25%)	8 (34%)
Number of organs with metastases
1	2 (25%)	5 (31%)	7 (29%)
2	3 (37.5%)	5 (31%)	8 (34%)
3+	3 (37.5%)	6 (38%)	9 (37%)