Table 2.
Odds Ratios and 95% Confidence Intervals for the Association Between Frequency of Non-steroidal Anti-inflammatory Drug Use and Risk of Barrett's Esophagus Compared with GERD Controls
| No. of studies | OR (95% CI) | I2 (95% UI) | ORa (95% CI) | I2 (95% UI) | |
|---|---|---|---|---|---|
| Aspirin use | |||||
| Nonuser (< weekly use) | 1.00 | 1.00 | |||
| At least weekly | 5 | 1.18 (0.92-1.52) | 57 (0-84) | 1.04 (0.82-1.30) | 40 (0-78) |
| Weekly-<daily | 4 | 1.17 (0.83-1.64) | 13 (0-87) | 1.06 (0.78-1.46) | 2 (0-85) |
| At least daily | 4 | 0.97 (0.61-1.54) | 72 (21-90) | 0.83 (0.51-1.33) | 69 (11-89) |
| Duration of use | |||||
| <5 years | 4 | 0.98 (0.61-1.58) | 74 (26-91) | 0.89 (0.53-1.48) | 75 (30-91) |
| ≥5 years | 4 | 1.27 (1.02-1.59) | 0 (0-78) | 1.14 (0.90-1.45) | 0 (0-73) |
| Non-aspirin NSAID use | |||||
| Nonuser (< weekly use) | 1.00 | 1.00 | |||
| At least weekly | 5 | 0.92 (0.69-1.23) | 51 (0-82) | 0.94 (0.76-1.16) | 3 (0-80) |
| Weekly-<daily | 4 | 0.85 (0.62-1.15) | 0 (0-82) | 0.85 (0.62-1.18) | 0 (0-80) |
| At least daily | 4 | 0.89 (0.56-1.43) | 54 (0-85) | 0.93 (0.62-1.39) | 32 (0-76) |
| Duration of use | |||||
| <5 years | 4 | 0.83 (0.58-1.17) | 30 (0-74) | 0.84 (0.62-1.13) | 0 (0-83) |
| ≥5 years | 4 | 0.97 (0.71-1.32) | 0 (0-64) | 1.00 (0.72-1.38) | 0 (0-73) |
| Any NSAID use | |||||
| Nonuser (< weekly use) | 1.00 | 1.00 | |||
| At least weekly | 5 | 1.07 (0.86-1.34) | 52 (0-82) | 0.99 (0.82-1.19) | 19 (0-83) |
| Weekly-<daily | 4 | 1.05 (0.81-1.36) | 0 (0-39) | 1.00 (0.76-1.31) | 0 (0-17) |
| At least daily | 4 | 0.99 (0.71-1.38) | 59 (0-86) | 0.90 (0.68-1.20) | 37 (0-78) |
| Duration of use | |||||
| <5 years | 4 | 0.84 (0.62-1.14) | 44 (0-81) | 0.79 (0.56-1.10) | 48 (0-83) |
| ≥5 years | 4 | 1.12 (0.90-1.39) | 0 (0-74) | 1.03 (0.82-1.29) | 0 (0-57) |
a
Models included terms for age (<50, 50-59, 60-69, ≥70 years), sex (except NDB, all male), education (school only, tech/diploma, university), smoking status (never, former, current) and body mass index (<25, 25-29.9, ≥30 kg/m2).