Table 3.
Adjusted Odds Ratios and 95% Confidence Intervals for the Association Between Frequency of Non-steroidal Anti-inflammatory Drug Use and Risk of Barrett's Esophagus Compared with Population-based Controls, Stratified by GERD Symptoms
| No. of studies | OR (95% CI) | I2 (95% UI) | |
|---|---|---|---|
| Less than weekly GERD symptoms | |||
| Aspirin use | |||
| Nonuser (< weekly use) | 1.00 | ||
| At least weekly | 6 | 1.06 (0.66-1.70) | 40 (0-76) |
| Non-aspirin NSAID use | |||
| Nonuser (< weekly use) | 1.00 | ||
| At least weekly | 6 | 1.13 (0.47-2.71) | 61 (6-84) |
| Any NSAID use | |||
| Nonuser (< weekly use) | 1.00 | ||
| At least weekly | 6 | 0.94 (0.53-1.65) | 57 (0-83) |
| At least weekly GERD symptoms | |||
| Aspirin use | |||
| Nonuser (< weekly use) | 1.00 | ||
| At least weekly | 6 | 0.98 (0.73-1.32) | 36 (0-74) |
| Non-aspirin NSAID use | |||
| Nonuser (< weekly use) | 1.00 | ||
| At least weekly | 6 | 1.30 (0.99-1.70) | 16 (0-79) |
| Any NSAID use | |||
| Nonuser (< weekly use) | 1.00 | ||
| At least weekly | 6 | 1.12 (0.88-1.42) | 17 (0-62) |
Models included terms for age (<50, 50-59, 60-69, ≥70 years), sex (except NDB, all male), education (school only, tech/diploma, university), smoking status (never, former, current), and body mass index (<25, 25-29.9, ≥30 kg/m2)