Fig. 2.

Placental mTOR signaling inhibition in an in vitro model of placental malaria-associated intervillositis. mTOR activity was determined as the phosphorylated-to-total protein expression levels of rps6, 4EBP-1, and Akt in primary human trophoblast cells exposed to infected conditioned medium, uninfected conditioned medium, and culture medium alone. a Representative Western blot. b mTOR signaling activity and c System A activity are decreased in primary human trophoblast cells exposed to infected conditioned medium. n = 4 placentas. CM conditioned medium, Control culture medium alone