Fig. 3.

Preservation heat map of co-expression gene modules in independent datasets shows level of module preservation in the human placenta across human gestation and in mid gestation mouse placenta (E11.5). Colours represent four classes of co-expression preservation as represented by Z-score summary of preservation statistics. Z _summary>10 indicates high level of evidence for module preservation, Z _summary 5-10 indicates moderate-high preservation, Z _summary 2-5 indicates low-moderate preservation, and Z _summary<2 indicates no evidence for preservation. Numbers within cells are the Z _summary statistic. Third trimester reference (far left column) represents results from running permutation tests using the data collected in this study. Third trimester validation data (n=20) is from ref [11]. Second trimester gene expression data (n=27,GSE5999) is from ref [2]. First trimester expression data (n=16, GSE28551) is from ref [1]. Mouse expression data at E11.5 (n=23, SRA062227) is from ref [24]