Figure 2.

Suggested diagnostic work-up for patients with suspected IBS and no alarm features. Alarm features include age ≥50 years, blood in stool, nocturnal symptoms, unintentional weight loss, change in symptoms, recent antibiotic use, and a family history of organic disease. C, constipation; CBC, complete blood count; CdtB, cytolethal distending toxin B; CRC, colorectal cancer; CRP, C-reactive protein; D, diarrhea; IBS, irritable bowel syndrome; IgA, immunoglobulin A; M, mixed diarrhea and constipation; SeHCAT, selenium homocholic acid taurine; Ttg, tissue transglutaminase. Adapted from Chey WD et al. JAMA. 2015;313(9):949-958³ and Pimentel M et al. PLoS ONE. 2015;10(5):e0126438.³⁵