Table 3.
Significance of changes in gene expression in PAH MPCs versus control
| PAH versus control | |||
|---|---|---|---|
| Gene symbol | Adjusted P value | Fold change | Comments |
| SPON2 | 0.0386202 | 2.16564 | LRP6 ligand, canonical Wnt activator21,22 |
| PEAR1 | 0.00635016 | 2.12031 | Platelet endothelial aggregation receptor 1, platelet aggregation23 |
| TNC | 0.0348311 | 2.2882 | Matrix, increased in PAH24 |
| NEO1 | 0.0329007 | 2.37015 | BMP receptor, neogenin25 |
| DKK1 | 0.0201554 | −2.27936 | Dickkopf1, a canonical Wnt inhibitor and LRP6 ligand26 |
| PDK4 | 4.00E−05 | −2.98576 | Wnt gene target and regulator of metabolism, pyruvate dehydrogenase kinase-isozyme 427,28 |
| WLS | 0.0328988 | −2.07564 | Members or targets of Wnt signaling |
| RGS5 | 0.00629714 | −3.45307 | Regulator of G-protein signaling 5, vascular tone29,30 |
| PTGS2 | 0.040118 | −5.5725 | Cyclooxygenase-2/cox2, vascular tone29,30 |
Note
BMP: bone morphogenetic protein; PAH: pulmonary arterial hypertension.