Table 3.
Spearman correlation coefficients and P values for association of angiopoietin-2 (Ang-2) and soluble P-selectin (sP-selectin) levels with clinical parameters at week 16 in patients receiving oral treprostinil (n = 83)
| Correlation coefficient (P value) | 6MWD at week 16, m | NYHA/WHO functional class at week 16 | NT-proBNP at week 16, pg/mL | Oral treprostinil dose at week 16, mg BID |
|---|---|---|---|---|
| Ang-2 at baseline, ng/mL | −0.19 (0.0906) | 0.19 (0.0940) | 0.59 (<0.0001a) | −0.18 (0.1148) |
| sP-selectin at baseline, ng/mL | −0.15 (0.1747) | 0.07 (0.5279) | 0.08 (0.4899) | 0.06 (0.5831) |
| Ang-2 change from baseline, ng/mL | −0.05 (0.6530) | 0.10 (0.3481) | 0.06 (0.5995) | −0.00 (1.0000) |
| sP-selectin change from baseline, ng/mL | 0.02 (0.8646) | −0.09 (0.4076) | −0.01 (0.9131) | −0.06 (0.6092) |
Note
6MWD: 6-minute walk distance; BID: twice daily; NT-proBNP: N-terminal pro-brain natriuretic peptide; NYHA: New York Heart Association; WHO: World Health Organization.
a
Significant at type I error level of 0.05.