Figure 2.

Three-dimensional lumen diameter maps of individual right lung lobes. A–D, Control superior, middle, inferior, and accessory lobes, respectively; E–H, SU/hyp superior, middle, inferior, and accessory lobes, respectively. I, Ratio of the total lung vascular volume to total lung volume for control and SU/hyp lungs as a function of arterial lumen diameter (scale bar range: 0.000–0.200 mm). SU/hyp: rat model of pulmonary arterial hypertension using a subcutaneous injection of vascular endothelial growth factor receptor blocker (Sugen 5416) with subsequent exposure to hypoxic conditions.