Table 3.
Key study outcomes at each 8-week interval as compared with baseline
| Characteristic | Week 0 | Week 8 | Week 16 | Week 24 |
|---|---|---|---|---|
| 6-minute walk distance, m (n = 6) | 419.1 ± 170.1 | 418.1 ± 143.5 | 436.5 ± 178.1 | 377.1 ± 140.9 |
| Oxygen saturation at rest, % (n = 6) | 96.5 ± 1.8 | 95.2 ± 2.6 | ||
| Oxygen desaturation (at nadir) during 6MWT, % (n = 6) | 9 ± 6 | 9 ± 9 | ||
| Maximum Borg score during 6MWT (n = 6) | 4.8 ± 1.2 | 5.0 ± 2.4 | 5.3 ± 2.1 | 6.3 ± 2.3 |
| Brain natriuretic peptide, pg/mL | 58.8 ± 89.6 | 32.3 ± 46.6 | 37.5 ± 51.4 | 42.6 ± 49.7 |
| SF-36 global score | 38.5 ± 5.3 | 37.7 ± 6.7 | 39.2 ± 6.5 | 38.9 ± 8.5 |
| SGRQ total score | 64.5 ± 15.5 | 65.1 ± 18.9 | 64.3 ± 15.2 | 71.1 ± 15.2 |
| WHO functional class, no. | ||||
| 1 | 0 | 1 | 1 | 1 |
| 2 | 3 | 2 | 2 | 2 |
| 3 | 4 | 4 | 4 | 4 |
| 4 | 0 | 0 | 0 | 0 |
Note
Outcomes determined on the basis of 7 patients who completed the study, unless noted otherwise. Except where otherwise indicated, data are means ± SD. 6MWT: 6-minute walk test; SF-36: short form 36; SGRQ: St. George’s respiratory questionnaire; WHO: World Health Organization.