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. 2016 Dec 19;18(1):5–7. doi: 10.15252/embr.201643634

Figure 1. Polarized effects of Bin1 and CD2AP expression on intracellular Aβ42 pools.

Figure 1

Bin1 regulates endocytic recycling of BACE1 particularly in axons/presynapse, while CD2AP controls delivery of APP to intraluminal vesicles and lysosomal degradation in dendrites/postsynapse. Knocking down Bin1 increases BACE1 in axonal endosomes, while silencing CD2AP expression blocks sorting of APP to ILVs in dendritic endosomes (rectangles in top and bottom parts, respectively). In both events, production of endosomal Aβ42 is increased.