Table 1.

At a glance reference of published genetically engineered mouse models of UCC⁵⁷
[Matt to advise on whether permission is needed to reproduce.]

Mutation	Promoter	Phenotype	References
Hras+ (low copy) Hras+ (high copy)	UPII UPII	Low grade, non-invasive (long latency) Low grade, non-invasive (short latency)	Zhang, 200144 Zhang, 200144
Egfr+ Egfr+Hras+	UPII UPII	Hyperplasia Hyperplasia	Cheng, 200245 Cheng, 200245
Fgfr3+ Fgfr3+KrasG12D Fgfr3+β-cateninexon3/+ Fgfr3+Ptenfl/fl	UPII UPII UPII UPII	Hyperplasia Hyperplasia Hyperplasia Hyperplasia	Ahmad, 201146 Ahmad, 201146 Ahmad, 201146 Foth, 201447
Ncstnfl/fl	R26rtTA; tetO-	Invasive UCC	Rampias, 201448
p53fl/fl p53fl/fl p53fl/flHras+ p53fl/flPtenfl/fl	UPII UPKII UPII Adeno-Cre	Hyperplasia and dysplasia No phenotype High grade, invasive UCC Invasive, metastatic UCC	Gao, 200449 Ayala de la Peña, 201150 Gao, 200449 Puzio-Kuter, 200951
Ptenfl/fl Ptenfl/fl Ptenfl/fl Ptenfl/fl	Fabp-Cre Ksp-Cre Adeno-Cre UPII	Low grade UCC UCC of renal pelvis No phenotype No phenotype	Yoo, 2006,52 Tsuruta, 200653 Qian, 200954 Puzio-Kuter, 200951 Ahmad, 201134
Rb-/- Rb-/-Ptenfl/fl Rb-/-p53fl/fl	UPII Adeno-Cre UPII	No phenotype No phenotype Invasive UCC after chemical carcinogenesis	He, 200955 Puzio-Kuter, 200951 He, 200955
SV40 T antigen (low copy) SV40 T antigen (high copy) SV40 T antigen	UPII UPII UPKII	Carcinoma in situ Invasive, metastatic UCC Carcinoma in situ	Zhang, 199956 Zhang, 199956 Ayala de la Peña, 201150
β-cateninexon3/+ β-cateninexon3/+Ptenfl/fl β-cateninexon3/+HrasQ61L	UPII UPII UPII	Hyperplasia Low grade, non-invasive UCC Low grade, non-invasive UCC	Ahmad, 201134 Ahmad, 201134 Ahmad, 201135
UCC = urothelial cell carcinoma