Table 1.
C57BL/6 mouse groups and diets
| Genotype | Dietary Adenine | Dietary Iron |
|---|---|---|
| Wild-type | No | Low (4 ppm) |
| Wild-type | No | Standard (335 ppm) |
| Wild-type | Yes | Low (4 ppm) |
| Wild-type | Yes | Standard (335 ppm) |
| Hepcidin knockout | No | Low (4 ppm) |
| Hepcidin knockout | No | Standard (335 ppm) |
| Hepcidin knockout | Yes | Low (4 ppm) |
| Hepcidin knockout | Yes | Standard (335 ppm) |
Wild-type and hepcidin knockout mice were placed on 8-wk diets with low or standard iron concentrations, without or with adenine, which induces chronic kidney disease (CKD).