Figure 1.

Plasmodium berghei K173 infection is accompanied by a strong inflammatory response. Parasitemia (A) and WBC count (B) progressively increased from day 7 to day 18. Hepatic Tnf mRNA expression (C) increased from day 1 to day 18 in the liver of mice infected with PbK. Similarly, Interferon-γ (Ifn-γ) expression (D) significantly increased by day 2 and reached a plateau at day 5 after infection with PbK. Data shown are mean ± sem and were compared for each time point to values for control mice at t=0 (n=5 to 10 mice per group except at day 18 where only 3 mice had survived) by one-way ANOVA. ***P<0.001, **P<0.01, *P<0.05. WBC: white blood cell; PbK: Plasmodium berghei K173.