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. 2017 Jan;102(1):e1–e6. doi: 10.3324/haematol.2016.154153

Figure 1.

Figure 1.

Linear regression relationship of urine ACR (albumin-to-creatinine ratio) with age by genotype. Individuals with APOL1 G1/G2 (β=1.5, 95% CI: 0.8 to 2.2), absence of α-thalassemia (β=1.0, 95% CI: 0.6 to 1.5), and wild-type BCL11A rs1427407 (β=0.7, 95% CI: 0.2 to 1.2) had higher urine ACR than individuals with wild-type APOL1, α-thalassemia, and the BCL11A rs1427407 T variant, respectively. A genetic profile integrating these three variants identified individuals with progressively higher urine ACR (β=1.5, 95% CI: 1.0 to 2.0). Linear regression lines by genetic variant or genetic risk profile are provided in the figures.