Figure 3.

CKD (chronic kidney disease) progression. CKD progression, defined as a reduction of estimated glomerular filtration rate by 50% or requiring renal replacement therapy, occurred at higher rates based on (A) APOL1 G1/G2, (B) a genetic profile incorporating APOL1, α-thalassemia, and the BCL11A rs1427407 variant, and (C) the genetic profile in the subset of sickle cell anemia individuals with APOL1 G1/G2. Log-rank P-values are provided in the figures. G1/G2, homozygosity or compound heterozygosity for the G1 and G2 risk variants; high-risk, co-inheritance of APOL1 G1/G2, absence of α-thalassemia, and wild-type BCL11A; low-risk, co-inheritance of wild-type APOL1, α-thalassemia, and the BCL11A rs1427407 T variant; intermediate-risk, all other combinations.