Fig. 6.

Lipid biosynthesis in Y. lipolytica. The localization of enzymes involved in production of lipids from citrate is shown along with results from our analysis of localization. Enzyme names with multiple colors indicate localization to more than one compartment. ACL ATPcitrate lyase, ACC Acetyl-CoA carboxylase, ALE1 1-acyl-sn-glycerol-3-P acyltransferase, ARE Acyl-CoA:sterol acyltransferase, CDS CDP-diglyceride synthase, CEM1 β-ketoacyl synthase, DGA Diacylglycerol acyltransferase, DGK Diacylglycerol kinase, FAS Fatty acid synthase, LOA1 1-acyl-sn-glycerol-3-P acyltransferase, LRO1 Phospholipid:diacylglycerol acyltransferase, PAH1 Phosphatidate phosphatase, SLC1 1-acyl-sn-glycerol-3-P acyltransferase, SCT1 Glycerol-3-P o-acyltransferase, TGL Triacylglycerol lipase. G3P glycerol-3-phosphate, LPA lyso-phosphatidic acid, PA phosphatidic acid, DAG diacylglycerol, TAG triacylglycerol, FFA free fatty acid