Table 4.

Summary of variant callers used for available benchmarks and their support for replicates

Variant caller	Support for	gDNA vs. cDNA	cDNA vs. cDNA
	replicates
SAMtools/BCFtools	x	x	x
REDItools		xa
MuTect		x
JACUSA	x	x	x

^aThe REDItools package supplies multiple methods to identify RNAediting sites. We employed the REDItoolDenovo.py script because it provides a test-statistic. This method only utilizes RNA-Seq reads