Table 4.
Incidence Rates and Hazard Ratios for VTE, DVT, and PE According to Ischemic Stroke Exposure by the Presence of Predisposing Factors
| Person‐Years | VTE Events | Crude IR (95% CI)a | Model 1b HR (95% CI) | Model 2c HR (95% CI) | Model 3d HR (95% CI) | |
|---|---|---|---|---|---|---|
| Provoked VTE | ||||||
| No stroke | 361 634 | 332 | 0.9 (0.8–1.0) | Reference | Reference | Reference |
| <3 months | 294 | 14 | 47.6 (28.2–80.4) | 19.3 (11.2–33.2) | 18.8 (10.9–32.4) | 22.6 (12.5–40.9) |
| >3 months | 5193 | 22 | 4.2 (2.8–6.4) | 1.1 (1.1–2.6) | 1.5 (1.0–2.4) | 1.9 (1.1–3.0) |
| Unprovoked VTE | ||||||
| No stroke | 361 634 | 333 | 0.9 (0.8–1.0) | Reference | Reference | Reference |
| <3 months | 294 | 4 | 13.6 (5.1–36.2) | 5.5 (2.0–14.8) | 5.3 (1.9–14.2) | 7.4 (2.7–20.1) |
| >3 months | 5193 | 17 | 3.3 (2.0–5.3) | 1.3 (0.8–2.2) | 1.3 (0.8–2.1) | 1.4 (0.8–2.5) |
| Provoked DVT | ||||||
| No stroke | 361 634 | 216 | 0.6 (0.5–0.7) | Reference | Reference | Reference |
| <3 months | 294 | 8 | 27.2 (13.6–54.4) | 17.5 (8.5–35.8) | 17.2 (8.4–35.2) | 19.7 (9.1–42.7) |
| >3 months | 5193 | 12 | 2.3 (1.3–4.1) | 1.4 (0.8–2.6) | 1.3 (0.7–2.4) | 1.4 (0.7–2.8) |
| Unprovoked DVT | ||||||
| No stroke | 361 634 | 170 | 0.5 (0.4–0.5) | Reference | Reference | Reference |
| <3 months | 294 | 2 | 6.8 (1.7–27.2) | 5.9 (1.4–23.8) | 5.8 (1.4–23.4) | 7.2 (1.8–29.6) |
| >3 months | 5193 | 7 | 1.3 (0.6–2.8) | 1.2 (0.5–2.5) | 1.1 (0.5–2.5) | 1.3 (0.6–3.0) |
| Provoked PE | ||||||
| No stroke | 361 634 | 116 | 0.3 (0.3–0.4) | Reference | Reference | Reference |
| <3 months | 294 | 6 | 20.4 (9.2–45.4) | 22.4 (9.7–51.8) | 21.8 (9.4–50.1) | 29.0 (11.5–73.6) |
| >3 months | 5193 | 10 | 1.9 (1.0–3.6) | 2.0 (1.0–3.9) | 1.9 (1.0–3.7) | 2.8 (1.3–5.7) |
| Unprovoked PE | ||||||
| No stroke | 361 634 | 163 | 0.5 (0.4–0.5) | Reference | Reference | Reference |
| <3 months | 294 | 2 | 6.8 (1.7–27.2) | 5.2 (1.3–21.0) | 4.8 (1.2–19.7) | 7.7 (1.9–31.5) |
| >3 months | 5193 | 10 | 1.9 (1.0–3.6) | 1.4 (0.7–2.8) | 1.3 (0.7–2.6) | 1.6 (0.7–3.4) |
The Tromsø Study 1994–2010. DVT indicates deep vein thrombosis; HR, hazard ratio; IR, incidence rate; PE, pulmonary embolism; VTE, venous thromboembolism.
a
Per 1000 persons‐years.
b
Model 1: Age as timescale, adjusted for sex.
c
Model 2: Model 1+body mass index.
d
Model 3: Model 2+systolic blood pressure, diabetes mellitus, high‐density lipoprotein cholesterol, smoking, physical activity, and education level.