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. 2016 Oct 26;5(11):e004594. doi: 10.1161/JAHA.116.004594

Figure 2.

Figure 2

Effect of Giα‐2 and Giα‐3 knockdown on the development of high blood pressure (BP). Antisense (AS) or sense of Giα‐2 and Giα‐3 encapsulated in PEG‐cationic liposomes (1 mg/kg body weight) and empty liposomes were injected intravenously via tail vein once into prehypertensive spontaneously hypertensive rats (SHRs) aged 3 weeks and age‐matched Wistar Kyoto (WKY) rats. A second injection of AS Giα‐2 (1 mg/kg body weight) was given at 8 weeks to the AS‐treated SHR group. Systolic BP (A and D), diastolic BP (B and E), and mean arterial BP (C and F) were monitored weekly using the CODA system until rats were aged 9 weeks. Values are mean±SD of 6–10 rats in each group. ***P<0.001 vs WKY control, ### P<0.001 vs SHR control.