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Effect of knockdown of Giα‐2 antisense (AS) on M2 receptor‐dependent Gi functions. Adenylyl cyclase activity was determined in the absence or presence of 5 μmol/L oxotremorine in heart particulate fractions from control (CTL) and Giα‐2 AS‐treated 6‐week‐old spontaneously hypertensive rats (SHRs) and Wistar Kyoto (WKY) rats. Values are mean±SD of 4 separate experiments using different rats from each group. ***P<0.001 vs WKY CTL; ## P<0.01 vs SHR CTL. NS indicates not significant.
