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. 2016 Nov 10;5(11):e003922. doi: 10.1161/JAHA.116.003922

Figure 4.

Figure 4

Cardiac and fibroblast marker gene expression profile following reprogramming factor administration. A, mRNA expression of cardiomyocyte marker genes (TNNT2, MYH6, TNNC1, NPPA, and RYR2) in porcine cardiac fibroblasts 2 weeks after transduction with GMT plus other reprogramming factors, as determined by qRT‐PCR (n=3). B, mRNA expression of fibroblast marker genes (COL1A1 and COL3A1) in porcine cardiac fibroblasts 2 weeks after transduction with GMT plus other reprogramming factors, as determined by qRT‐PCR (n=3). Data were normalized against the GFP values. All the data presented as mean±SEM. *P<0.05 versus GFP (Kruskal–Wallis test). COL indicates collagen; cTnT, cardiac troponin T; DAPI, 4′,6‐diamidino‐2‐phenylindole; GFP, green fluorescent protein; miR, microRNA; NPPA, natriuretic peptide; qRT‐PCR, quantitative reverse‐transcription polymerase chain reaction; RYR2, ryanodine receptor‐2.