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. 2016 Nov 14;5(11):e003697. doi: 10.1161/JAHA.116.003697

Figure 2.

Figure 2

The therapeutic effects of PVAX and HPOX nanoparticles on hind limb I/R injury. A and B, Quantification of caspase‐3 (A) and PARP activity (B) *P<0.05 vs sham of each group; † P<0.05 vs HPOX I/R. (n=4/group). Mann‐Whitney test was used. C, Expression of inflammatory markers TNF‐α and MCP‐1 in hind limb I/R injury. D and E, Quantification of TNF‐α (D) and MCP‐1 (E) mRNA level, *P<0.05 vs sham of each group; † P<0.05 vs HPOX I/R. (n=4/sham group, n=6/I/Rgroup). ANOVA and Bonferroni test were used. F, Representative images of gastrocnemius muscle tissues stained by hematoxylin and eosin (×200). I/R indicates ischemia/reperfusion; MCP‐1, monocyte chemotactic protein‐1; TNF‐α, tumor necrosis factor‐α.