Table 3.
Comparison of Hemodynamic Variables During the First 72 Postoperative Hours Prior to and Following Implementation of the Treatment Algorithm
| Variable | N | P Value | Magnitude of Algorithm Effectsa | ||
|---|---|---|---|---|---|
| Difference at 0 Hours (95% CI)b | Difference at 36 Hours (95% CI)b | Difference at 72 Hours (95% CI)b | |||
| Mean Difference at Hours 0 to 72 (95% CI)f | |||||
| SBF, L/(min·m2) | 795 | 0.09 | 0.53 (0.1, 1.1) | ||
| iDO2, mL/(min·m2) | 795 | 0.19 | 70.1 (−34.2, 174.5) | ||
| iSVR, iWUc | 763 | 0.01 | −66 (−115, −16) | −41 (−83, 0.9) | −16 (−66, 35) |
| iVO2, mL/(min·m2) | 880 | 0.22 | 21.61 (17.69) | ||
| COD, L/m2 | 1306 | 0.56 | 54.1 (−129.6, 239.5) | ||
| Mean BP, mm Hge | 3534 | <0.001 | −6 (−8, −4) | −4 (−6, −2) | −2 (−4, 0.2) |
| CVP, mm Hg | 3499 | 0.13 | −0.9 (−2.0, 0.2) | ||
| Heart rate, bpm | 3538 | 0.84 | −0.5 (−5.4, 4.3) | ||
| SaO2 (%)d | 3760 | 0.54 | 0.1 (−3, 4) | 0.1 (−3, 4) | −1 (−5, 3) |
| SvO2 (%)e | 3182 | <0.001 | 10 (4, 16) | 6 (0, 11) | 1 (−5, 7) |
| AVO2 diff (%)e | 3160 | <0.001 | −8 (−12, −4) | −5 (−9, −1) | −2(−6, 1.5) |
| Temperature, °C | 3069 | 0.27 | 0.2 (−0.1, 0.4) | ||
| Lactate, mmol/Le | 1246 | <0.001 | −3.4 (−5.1, −1.7) | −1.8 (−3.5, −0.1) | −0.2 (−2.1, 1.6) |
Model adjusted for nonlinear effect of time and random variability at a subject level. AVO2 diff indicates arteriovenous oxyhemoglobin difference; bpm, beats per minute; COD, cumulative oxygen debt; CVP, central venous pressure; iDO2, indexed systemic oxygen delivery; iSVR, indexed systemic vascular resistance; iVO2, indexed oxygen consumption; N, number of observations; SaO2, arterial oxyhemoglobin concentration; SBF, systemic blood flow; SvO2, venous oxyhemoglobin concentration.
Between‐group comparisons are post‐ minus preimplementation values, such that positive values represent higher values postimplementation and negative values represent lower values postimplementation.
When differences between groups differed significantly over time (ie, P<0.10 for the time interaction), between‐group differences are displayed at postoperative hours 0, 36, and 72.
P value for group and time interaction P=0.08.
P value for group and time interaction P=0.002.
P value for group and time interaction P<0.001.
When between‐group differences were not different over time, the mean between‐group difference is displayed.