Table 2.
Univariate Relationship of Clinical Parameters With the Slope of the Decline of eGFR
| Continuous Variables | r | P Value |
|---|---|---|
| Age at baseline, y | 0.002 | 0.96 |
| Weight, kg | −0.04 | 0.3 |
| Mean SBP, mm Hg | −0.13 | <0.001 |
| SD of SBP, mm Hg | −0.16 | <0.001 |
| CV of SBP, % | −0.14 | <0.001 |
| HbA1c, % | −0.15 | <0.001 |
| Total cholesterol, mmol/L | 0.03 | 0.41 |
| LDL cholesterol, mmol/L | 0.05 | 0.22 |
| Categorical Variables | Mean of eGFR Slope | P Value |
|---|---|---|
| Sex | ||
| Male (n=266) | −0.83 | 0.01 |
| Female (n=559) | −1.1 | |
| DM | ||
| Yes (n=539) | −1.26 | <0.001 |
| No (n=285) | −0.56 | |
| Treatment of hypertension | ||
| Yes (n=794) | −0.46 | 0.04 |
| No (n=31) | −1.04 | |
| ACE‐i | ||
| Yes (n=361) | −1.0 | 0.59 |
| No (n=464 | −1.0 | |
| ARB | ||
| Yes (n=201) | −1.36 | <0.001 |
| No (n=624) | −0.91 | |
| β‐Blocker | ||
| Yes (n=299) | −1.03 | 0.83 |
| No (n=526) | −1.00 | |
| CCB | ||
| Yes (n=509 | −1.03 | 0.76 |
| No (n=316) | −1.0 | |
| Diuretics | ||
| Yes (n=330) | −1.25 | 0.001 |
| No (n=495) | 0.86 | |
| α‐Blockers | ||
| Yes (n=50) | −1.57 | 0.02 |
| No (n=775) | −0.98 | |
| Lipid‐lowering medication | ||
| Yes (n=694) | −1.08 | 0.008 |
| No (n=131) | −0.70 | |
ACE‐i indicates angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; CCB, calcium channel blocker; CV, coefficient of variation; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; LDL, low‐density lipoprotein; SBP, systolic blood pressure.