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. 2016 Dec 30;4(24):e13055. doi: 10.14814/phy2.13055

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© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effect of chronic tempol treatment on oxidative stress indicators in rats with type 1 diabetes mellitus (T1D). (A) Representative images showing dihydroethidium oxidation (red fluorescence), indicative of superoxide production by glomeruli isolated from T1D and T1D+Tempol rats. (B) Urinary excretion of thiobarbituric acid reactive substances (TBARS). (C) Plasma TBARS levels (**P < 0.01 vs. T1D; number of animals shown at bottom of each bar).