Table 3.
Associations between GPIA rs1126643 and MACCE in Discovery Cohort and Replication Cohort
| GPIA rs1126643 | Discovery Cohort | Replication Cohort | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Frequency, % | HR | P Value | Adjusted HR | Adjusted P Value | Frequency, % | HR | P Value | Adjusted HR | Adjusted P Value | |||
| Without MACCE | With MACCE | Without MACCE | With MACCE | |||||||||
| CC | 81.2 | 18.8 | 90.8 | 9.2 | ||||||||
| CT+TT | 76.6 | 23.4 | 84.7 | 15.3 | ||||||||
| 1.292 (1.037–1.609) | 0.022a | 1.272 (1.020–1.587) | 0.033a | 1.739 (1.094–2.765) | 0.019a | 1.741 (1.092–2.773) | 0.020a | |||||
Adjusted risk factors are reported in Table S3. GPIA indicates glycoprotein Ia; HR, hazard ratio; MACCE, major adverse cardiac and cerebrovascular events.
a
Statistically significant (P<0.05).