Table 2.
MD and Risk of Incident Ischemic Heart Disease: Stratified Analysis and Sensitivity Analysis
| Incidence Rate (1000 Person‐Years) | Model 1 HR (95% CI) | Model 2 HR (95% CI) | Model 3 HR (95% CI) | P for Interactiona | |
|---|---|---|---|---|---|
| Overall | — | ||||
| No MD | 7.21 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 8.76 | 1.32 (1.14–1.52) | 1.30 (1.13–1.50) | 1.32 (1.15–1.53) | |
| Sex | 0.23 | ||||
| Men | |||||
| No MD | 7.34 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 9.55 | 1.53 (1.18–1.98) | 1.47 (1.13–1.91) | 1.50 (1.15–1.94) | |
| Women | |||||
| No MD | 7.12 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 8.47 | 1.25 (1.05–1.48) | 1.24 (1.05–1.48) | 1.26 (1.07–1.50) | |
| Age | 0.10 | ||||
| <60 years old | |||||
| No MD | 4.76 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 6.93 | 1.42 (1.19–1.69) | 1.39 (1.17–1.66) | 1.42 (1.19–1.69) | |
| ≥60 years old | |||||
| No MD | 16.35 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 17.42 | 1.14 (0.89–1.45) | 1.12 (0.88–1.43) | 1.15 (0.90–1.46) | |
| BMI | 0.98 | ||||
| <24 kg/m2 | |||||
| No MD | 6.26 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 7.88 | 1.33 (1.10–1.61) | 1.31 (1.09–1.59) | 1.31 (1.08–1.58) | |
| ≥24 kg/m2 | |||||
| No MD | 8.46 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 10.28 | 1.34 (1.08–1.66) | 1.33 (1.07–1.65) | 1.33 (1.07–1.66) | |
| Geographic location | 0.005 | ||||
| Rural | |||||
| No MD | 6.60 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 7.35 | 1.14 (0.94–1.38) | 1.12 (0.92–1.35) | 1.13 (0.93–1.37) | |
| Urban | |||||
| No MD | 8.03 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 11.65 | 1.72 (1.38–2.13) | 1.68 (1.35–2.08) | 1.72 (1.39–2.14) | |
| Excluding cases occurring within the first 2 years | — | ||||
| No MD | 5.68 | 1.00 | 1.00 | 1.00 | |
| Past year MD | 6.98 | 1.29 (1.10–1.51) | 1.27 (1.08–1.49) | 1.29 (1.10–1.52) | |
Model 1: adjusted for age, sex, geographic location, marital status, education, and annual household income; Model 2: model 1 plus smoking status, drinking status, and physical activity; Model 3: model 2 plus body mass index, history of diabetes mellitus and hypertension, and family history of heart attack. BMI indicates body mass index; HR, hazard ratio; MD, major depression.
a
P values for interaction were assessed by including an interaction term of MD and corresponding stratified factor in model 3.