Table 5.
Event Rates and Relative Risks for Major Bleeding and Aortic Valve Reoperation According to Kidney Function and Prosthesis Type in Patients With Normal Kidney Function (eGFR >60 mL/min per 1.73 m2) and Moderately Reduced Kidney Function (eGFR of 30–60 mL/min per 1.73 m2) Who Underwent AVR in Sweden Between 1997 and 2013
| Normal Kidney Function | Moderately Reduced Kidney Function | |||||
|---|---|---|---|---|---|---|
| Events/No. of Patients | Crude Rate (95% CI) per 1000 PY | HR (95% CI) | Events/No. of Patients | Crude Rate (95% CI) per 1000 PY | HR (95% CI) | |
| Major bleeding | 539/9105 | 10 (9–10) | 260/3100 | 12 (10–13) | ||
| Unadjusted | 1.00 | 1.20 (1.03–1.39) | ||||
| Multivariable adjusted modela | 1.00 | 1.18 (1.00–1.39) | ||||
| Bioprosthesis | 221/5134 | 1.00 | 173/2430 | 1.22 (0.99–1.52) | ||
| Mechanical valve prosthesis | 318/3971 | 1.00 | 87/670 | 1.07 (0.82–1.40) | ||
| Aortic valve reoperation | 265/9836 | 4 (3–4) | 39/3266 | 1 (1–2) | ||
| Unadjusted | 1.00 | 0.38 (0.27–0.53) | ||||
| Multivariable adjusted modela | 1.00 | 0.54 (0.38–0.79) | ||||
| Bioprosthesis | 155/5676 | 1.00 | 23/2582 | 0.40 (0.25–0.63) | ||
| Mechanical valve prosthesis | 110/4160 | 1.00 | 16/684 | 1.03 (0.59–1.79) | ||
AVR indicates aortic valve replacement; eGFR, estimated glomerular filtration rate; HR, hazard ratio; PY, person‐years.
a
The multivariable model included all variables in Table 3.