Table 2.
Characteristics of the variables related to ventricular repolarization in cirrhotic subjects, evaluated according to disease severity and clinical outcome
| Variable | Child A (N: 25) | Child B (N: 26) | Child C (N: 16) | p* | Survivors (N=) | Death/transp (N=) | p† |
|---|---|---|---|---|---|---|---|
| RR interval (ms) | 922 ± 138 | 955 ± 130 | 866 ± 141 | 0.12 | 922 ± 135 | 911 ± 134 | 0.69 |
| Maximum QT (ms) | 413.6 ± 32.1 | 425.3 ± 27.3 | 413.3 ± 32.9 | 0.40 | 419.0 ± 32.4 | 417.9 ± 26.3 | 0.96 |
| Minimum QT (ms) | 369.7 ± 31.5 | 383.8 ± 29 | 376.5 ± 30.7 | 0.34 | 376.7 ± 30.6 | 376.8 ± 26.5 | 0.99 |
| Mean QT (ms) | 394.2 ± 32.7 | 407.1 ± 25.3 | 395.3 ± 31.8 | 0.34 | 399.8 ± 32.2 | 400.5 ± 23.7 | 0.99 |
| QT > 460 ms (%) | 8.0% | 7.4% | 0.0% | 0.52 | 8.2% | 0.0% | 0.48 |
| DQT (ms) | 43.9 ± 17.7 | 41.5 ± 21.9 | 36.9 ± 9.9 | 0.52 | 41.8 ± 19.2 | 41.1 ± 14.9 | 0.91 |
| DQT > 60 ms (%) | 16.0% | 14.8% | 0.0% | 0.39 | 6.1% | 10.5% | 0.92 |
| Maximum QTc (ms) | 447.5 ± 72.7 | 442.1 ± 23.6 | 447.6 ± 22.9 | 0.91 | 446.9 ± 54.4 | 441.6 ± 20.9 | 0.54 |
| Minimum QTc (ms) | 387.7 ± 30.8 | 393.2 ± 31.5 | 403.9 ± 22.8 | 0.28 | 393.1 ± 31.7 | 395.3 ± 25.7 | 0.97 |
| Mean QTc (ms) | 414.6 ± 33.8 | 418 ± 20.9 | 426.4 ± 21.8 | 0.45 | 417.8 ± 27.9 | 421.6 ± 22.9 | 0.73 |
| QTc > 460ms | 20.0% | 22.2% | 25.0% | 0.77 | 22.4% | 10.5% | 0.44 |
| DQTc (ms) | 59.8 ± 59.7 | 48.8 ± 22.9 | 43.7 ± 12.1 | 0.44 | 53.5 ± 44.8 | 46.8 ± 16.0 | 0.36 |
| DQTc > 60 ms | 24.0% | 22.2% | 6.3% | 0.38 | 18.4% | 15.8% | 0.92 |
| Maximum TpTe (ms) | 87.2 ± 17.3 | 85.3 ± 11.4 | 82 ± 12.3 | 0.36 | 86.3 ± 15.1 | 78.4 ± 9.6 | 0.015 |
| Minimum TpTe (ms) | 54.3 ± 8.5 | 50.8 ± 8.3 | 56.1 ± 10.7 | 0.23 | 54.7 ± 9.4 | 50.5 ± 7.1 | 0.028 |
| Mean TpTe (ms) | 70 ± 6.9 | 67.9 ± 6.7 | 71.1 ± 8.8 | 0.45 | 70.8 ± 7.3 | 66.8 ± 8.2 | 0.029 |
| TpTe ≤ 50 ms‡ | 32.0% | 51.9% | 37.5% | 0.50 | 40.8% | 73.7% | 0.03 |
*
One-way ANOVA; unpaired Student’s t test;
‡
optimal cutoff value calculated after analysis of the respective ROC; data are represented as mean
±
SD or percentage; TpTe: interval between the peak and the end of the T wave; QT: QT interval; QTc: corrected QT interval; DQT: QT interval dispersion; DQTc: QTc interval dispersion; Child: Child-Pugh-Turcotte classification; Transp: liver transplantation (see text for details).