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. 2016 Oct 28;45(Database issue):D228–D235. doi: 10.1093/nar/gkw1019

Table 1. Description of fields in the Expanded Entry page.

Field Description Source
Biological function Protein/assembly function(s) with specification to the fuzzy region. Uniprot, PubMed*
Domain organization/ sequence features Topological organization of the protein, ID regions and domains. Main sequence features. Chimera sequences. Pfam, Uniprot, PubMed
Structural evidence Structural data demonstrating structural multiplicity or dynamic disorder in the complex. PDB, BMRB, references
Biochemical evidence Functional data demonstrating the impact of the fuzzy region in the formation, activity or regulation of the assembly. references
Structure/mechanism Molecular mechanism of how fuzzy region(s) modulate the conformational ensemble and the function of the assembly. derived information, references
Mechanism category Mechanistic classification of the fuzzy region. derived information
Post-translational modification The role of PTMs interfering with the fuzzy region and their impact on the activity of the complex. Uniprot, references, derived information
Isoforms, context-dependence Different isoforms, generated by alternative splicing affecting the fuzzy region. Functional and context-specific features of the different isoforms. Uniprot, references, derived information
Medical relevance Involvement in different diseases, specific roles of the fuzzy regions. Uniprot, Cosmic, literature
Significance The relationship between fuzziness and the function of the assembly. derived information
Further reading Additional references. PubMed

*PubMed means a general literature search, references refer to the articles specified in FuzDB.