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. 2016 Nov 29;45(Database issue):D432–D439. doi: 10.1093/nar/gkw1037

Figure 1.

Figure 1.

An example of activating crosstalk. (A) The Notch signaling pathway. When the Delta ligand binds to Notch, the Notch intracellular domain (NICD) is cleaved and translocates to the nucleus, where it binds to CSL. The NICD:CSL complex controls the transcription of developmental genes. (B) The TGF-β signaling pathway. The binding of TGF-β to its receptor results in the heterodimerization of SMAD3 and SMAD4 and the subsequent phosphorylation and translocation of the complex to the nucleus. Here, this complex regulates the transcription of genes involved in differentiation. (C) Crosstalk from the Notch signaling pathway to the TGF-β signaling pathway occurs when NICD binds to SMAD3 to further promote complex formation between SMAD3 and SMAD4. After crosstalk, the transcriptional complex includes NICD (not shown in the figure).