Table 4. NIHR-RD-TRC assessment of HPO maturity.

Theme	Foundation	Formulation	Refinement	Maturity
Cancer	✓✓✓✓	✓✓
Cardiovascular	✓✓✓✓✓	✓✓✓	✓✓
Central Nervous System	✓✓✓
Eye Diseases	✓✓✓✓✓	✓✓✓✓✓	✓✓✓✓✓	✓✓
Gastrointestinal	✓✓✓✓	✓✓✓
Immunological Disorders	✓✓✓✓✓	✓✓✓	✓✓
Paediatric (cross-cutting)	✓✓✓✓✓	✓✓✓	✓✓✓	✓
Metabolic & Endocrine Diseases	✓✓✓✓✓	✓✓
Musculoskeletal Disorders	✓✓✓✓✓	✓✓✓✓✓	✓✓✓
Muscle & Nerve Diseases	✓✓✓✓✓	✓✓✓	✓
Non-malignant Haematology	✓✓✓✓✓	✓✓✓✓✓	✓✓✓✓✓	✓✓✓
Renal	✓✓✓✓✓	✓✓✓✓✓	✓✓✓	✓
Respiratory Diseases	✓✓✓	✓
Skin Diseases	✓✓✓✓✓	✓✓✓✓✓	✓✓✓