Skip to main content
. 2016 Sep 1;45(Database issue):D750–D757. doi: 10.1093/nar/gkw767

Figure 2.

Figure 2.

RNA editing distribution along human tissues and a graphical overview of sites stored in REDIportal. A-to-I events collected in REDIportal derive from RNAseq data encompassing 55 human body sites grouped in 30 different tissues. The distribution of RNA editing events detected according to our computational workflow, depicted in Figure 1, are shown in (A) along tissue specific events (in blue). Here, tissue specific events are defined as sites edited at non-zero level in a unique tissue. RNA editing sites stored in REDIportal are classified in three main categories, shown in (B), depending on their location: (i) ALU, residing in Alu repetitive elements, (ii) REP, located in non-Alu repetitive elements and (iii) NONREP, placed in non repetitive regions. The vast majority of A-to-I changes occur in protein coding genes (73%) as shown in (C) and especially in intronic regions (D). In untranslated regions, RNA editing changes are more abundant in 3′ UTRs than in 5′ UTRs (D).