Table 1. Annotation entry statistics for mutLBSgenes and targetable_mutLBSgenes.
| Data type | # Entries | # mutLBSgenesa | # targetable_mutLBSgenesb |
|---|---|---|---|
| Total 2372 (%) | Total 744 (%) | ||
| Targetable genes | # genes | ||
| Human Kinomec | 267 | 267 (11.3%) | 267 (35.9%) |
| TRANSFACd | 216 | 216 (9.1%) | 216 (29.0%) |
| IUPHARe | 579 | 579 (24.4%) | 579 (77.8%) |
| Cancer driver genesf | 179 | 179 (7.5%) | 179 (24.1%) |
| Ligand binding site | # LBS | ||
| BioLiPg | 10 108 | 2372 (100.0%) | 744 (100.0%) |
| Mutation | # nsSNV | ||
| TCGAh | 11 873 | 2372 (100.0%) | 744 (100.0%) |
| Expression | # genes | ||
| TCGAi | 20 502 | 2372 (100.0%) | 744 (100.0%) |
| Expression with drug treatment | # genes | ||
| CCLEj | 19 931 | 2372 (100.0%) | 744 (100.0%) |
| Molecule | # molecules | ||
| DrugBankk | 8206 drugs | 865 (36.5%) | 378 (50.8%) |
| UniProtl | 2374 proteins | 2372 (100.0%) | 743 (99.9%) |
| BioLiPm | 6108 ligands | 1780 (75.0%) | 572 (76.9%) |
| Phenotype | # phenotype | ||
| DisGeNetn | 6761 disease ID | 1449 (61.1%) | 662 (85.5%) |
| ClinVaro | 107 phenotype ID | 80 (3.4%) | 49 (6.6%) |
| Conservation | # LBS | ||
| MUSCLE resultsp | 27 269 | 2371 (100.0%) | 744 (100.0%) |
aNumber of genes having ligand binding site mutations (mutLBSgenes).
bTargetable mutLBSgenes.
cKinases from The Human Kinome database.
dTranscription factors from TRANSFAC database.
eDrug target genes from IUPHAR database.
fSignificantly mutated genes in 18 TCGA cancer types.
gLigand binding sites from Ligand-protein binding database (BioLiP).
hSomatic non-synonymous single nucleotide variants (nsSNVs) from TCGA in 16 cancer types.
iExpression values from TCGA.
jAnti-cancer drug treated cell-line's gene expression data.
kmutLBSgenes related drug IDs from DrugBank database.
lProtein accession data from UniProt database.
mLigand binding to mutLBSgenes.
nGene-level disease annotation from DisGeNet database.
oMutation-level pathogenic information from ClinVar.
pConservation information across 8 species from MUSCLE.