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The Y617E mutant partially rescues B cell proliferation and immune response in Btk–/Tec– mice. (A) Splenic B cells were purified by using a B cell isolation kit and seeded in 96-well plates in triplicate with various stimulations. The culture was pulsed with 3H-thymidine at 40 h and harvested at 60 h. Serum IgM (B) and 2,4,6,-trinitrophenyl-Ficoll specific IgM (C) were measured by ELISA.
