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Mutagenesis of m1A in E. coli. The base composition at the lesion site for m1A processed in the designated cell strains was obtained by the REAP assay. This polyethyleneimine TLC plate reveals that m1A is weakly mutagenic. The assay reproducibly detected subtle differences in mutagenicity, such as the suppression of A to T mutations by AlkB (center lanes), and the enhancement of such mutations by SOS polymerases (right lanes).
